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Axid Prescription

Axid is prescribed for the treatment of duodenal ulcers and noncancerous stomach ulcers. Full-dose therapy for these problems lasts no longer than 8 weeks. However, your doctor may prescribe Axid at a reduced dosage after a duodenal ulcer has healed. The drug is also prescribed for the heartburn and the inflammation that result when acid stomach contents flow backward into the esophagus. Axid belongs to a class of drugs known as histamine H2 blockers.

Although Axid can be prescribed for up to 8-12 weeks, most ulcers are healed within 4 weeks of therapy.

Axid contains the active ingredient nizatidine, which is a type of drug known as an H2-receptor antagonist. It works by reducing the production of stomach acid.

Nizatidine blocks histamine H2-receptors that are found on cells in the stomach lining. Normally, a substance called histamine binds to these receptors. Histamine is a chemical produced throughout the body and has many effects; when it binds to H2-receptors on cells in the stomach lining it causes them to produce acid.

Stomach acid is produced as a normal part of the digestive process. However, if large amounts of stomach acid are produced the excess acid may flow back into the food pipe (oesophagus), causing pain and a burning sensation known as heartburn. Excess stomach acid can also irritate the lining of the stomach and duodenum (an area of the intestine directly after the stomach). This lining normally resists attack from the stomach acid, but if the lining is damaged, for example due to treatment with non-steroidal anti-inflammatory drugs (NSAIDs such as ibuprofen), or large amounts of stomach acid are produced, a peptic ulcer can develop.

As nizatidine blocks the H2 receptors on the cells in the stomach, it prevents histamine from binding to them. This decreases the amount of stomach acid produced by these cells and lowers the amount of acid in the stomach and duodenum. This action helps to relieve the pain of heartburn, and helps ulcers to heal, including those caused by NSAIDs. By decreasing the production of stomach acid nizatidine can also be prescribed to prevent ulcers from recurring.

Why is Axid prescribed?

- treatment of peptic ulcers;
- preventing recurrence of peptic ulcers;
- gastro-oesophageal reflux disease;

Axid Side Effects

- weakness;
- vomiting;
- sore throat;
- pain;
- nausea;
- inflammation of the nose;
- indigestion;
- headache;
- gas;
- dizziness;
- diarrhea;
- yellowing of the skin and eyes (jaundice);
- sweating;
- sleepiness (somnolence);
- itchy rash (urticaria);
- inflammation of the liver (hepatitis);
- alteration in results of liver function tests;
- abdominal pain;

Axid Dosage

ADULTS

Active Duodenal Ulcer:

The usual dose is 300 mg once a day at bedtime, but your doctor may have you take 150 mg twice a day.

Active Noncancerous Stomach Ulcer:

The usual dose is 150 mg twice a day or 300 mg once a day at bedtime.

Maintenance of a Healed Duodenal Ulcer:

The usual dose is 150 mg once a day at bedtime.

If you have moderate to severe kidney disease, your doctor will prescribe a lower dose.

CHILDREN

The safety and effectiveness of Axid have not been established in children.