Prescription:

Colchicine was originally extracted from the autumn crocus but is now synthesised.

Colchicine binds to a substance found in white blood cells.

In gout, crystals of uric acid are deposited in certain joints. White blood cells migrate to the areas of the body where uric acid has been deposited. They attempt to engulf the crystals, and, as a result,lactic acid and pro-inflammatory enzymes are released. These substances give rise to the characteristic pain and swelling of gout.

Colchicine inhibits the migration of the white blood cells into the inflamed area, causing a reduction in pain and inflammation.


Why is this drug prescribed?

- short-term prevention of gout;
- acute gout;

Side Effects:

- rash;
- nausea and vomiting;
- loss of hair;
- disorder of the muscles;
- diarrhoea;
- decreased production of blood cells by the bone marrow;
- damage to the liver;
- damage to the kidneys;
- blood disorders;
- bleeding from the stomach;
- abdominal pain;
- "pins and needles" sensation in hands and feet;