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Gemfibrozil Indications

Gemfibrozil is prescribed, along with a special diet, for treatment of people with very high levels of serum triglycerides who are at risk of developing pancreatitis who do not respond adequately to a strict diet.

Gemfibrozil can also be prescribed to reduce the risk of coronary heart disease in people who have failed to respond to weight loss, diet, exercise, and other triglyceride- or cholesterol-lowering drugs.

Gemfibrozil contains the active ingredient gemfibrozil, which is a type of drug known as a fibrate. It works by reducing the production of fats by the liver. These lipids include cholesterol and triglycerides.

Cholesterol is one of the body's fats. Cholesterol and triglycerides are important building blocks in the structure of cells and are also prescribed in making hormones and producing energy. To some extent, the cholesterol level in blood depends on what you eat but it is mainly dependent on how the body makes cholesterol in the liver.

Having too much cholesterol in the blood is not a disease in itself, but can lead to the hardening and narrowing of the arteries.

For the sake of simplicity, there are two sorts of cholesterol; a 'bad' sort called low density lipoprotein and a 'good' sort called high density lipoprotein. LDL is deposited in the arteries and increases the risk of heart disease, while HDL actually protects the arteries against this. Triglycerides can also be considered as 'bad' fats; they also contribute to the risk of heart disease.

Gemfibrozil increases the breakdown of triglycerides already present in the body. It also decreases the production of triglycerides by the liver. This lowers triglyceride levels.

Gemfibrozil lowers LDL cholesterol by increasing the amount which is expelled from the gall bladder in the bile. In addition, it increases the levels of HDL cholesterol. The overall result of this is lowered levels of "bad fats" and raised levels of "good fats".

Fibrates have an important role in the prevention of heart disease. They reduce the risk of fats being deposited in the major blood vessels of the heart. Any blockage in the blood vessels limits the amount of blood and therefore oxygen being carried to the heart muscle. In severe cases this can result in a heart attack.

Gemfibrozil is only prescribed when blood lipid levels cannot be lowered by diet and exercise alone. It is important to follow a diet and exercise regime when taking gemfibrozil.


Why is Gemfibrozil prescribed?

- prevention of coronary heart disease in men aged 40-55 with hyperlipidaemia that has not responded to diet or other measures;
- high levels of fats such as cholesterol and triglycerides in the blood;

Gemfibrozil Side Effects

- vertigo;
- rash;
- nausea/vomiting;
- indigestion;
- headache;
- fatigue;
- eczema;
- diarrhea;
- constipation;
- acute appendicitis;
- yellowing of the skin and eyes;
- severe swelling of lips face or tongue;
- rash;
- rapid and irregular beating of the heart;
- muscle pain and weakness;
- muscle breakdown;
- itching;
- inflammation of the pancreas;
- impotence;
- headache;
- excess gas in the stomach and intestines;
- dizziness;
- disturbances of the gut such as diarrhoea constipation nausea vomiting or abdominal pain;
- blurred vision;
- abnormal reaction of the skin to light usually a rash;
- abdominal pain;

Gemfibrozil Dosage

ADULTS

The recommended dose is 1,200 mg divided into 2 doses, given 30 minutes before the morning and evening meals.

CHILDREN

Safety and effectiveness of Gemfibrozil have not been established for use in children.

OLDER ADULTS

Gemfibrozil should be prescribed with caution by older adults.