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Glibenclamide Indications

Daonil tablets contain the active ingredient glibenclamide, which is a type of drug called a sulphonylurea. Glibenclamide tablets are also available without a brand name, ie as the generic drug. Glibenclamide is prescribed to help control blood sugar levels in people with type 2 diabetes.

People with type 2 diabetes have a deficiency of a hormone called insulin. Insulin is produced by the pancreas and is the main hormone responsible for controlling sugar levels in the blood. It normally makes the cells of the body remove excess sugar from the blood. In type 2 diabetes insulin is produced inefficiently in response to surges of blood sugar, eg following a meal. The cells of the body also become resistant to the action of insulin that is produced, which means that blood sugar levels can become too high.

Glibenclamide works mainly by stimulating the cells in the pancreas that produce insulin. These cells are called beta cells. Glibenclamide causes the beta cells to produce more insulin. This helps to decrease the amount of sugar in the blood of people with type 2 diabetes.

Glibenclamide is a first line option for treating type 2 diabetes in people who are not overweight, or who cannot take metformin. Glibenclamide is prescribed when diet and exercise have failed to control blood sugar levels. Glibenclamide can also be prescribed in combination with other antidiabetic drugs to provide better control of blood sugar.

The tablets should normally be taken with, or immediately after, breakfast or the first main meal.

Why is Glibenclamide prescribed?

- Type 2 diabetes, when diet has failed to fully control blood sugar;

Glibenclamide Side Effects

- weight gain;
- temporary visual disturbances at start of treatment;
- low blood glucose level;
- inflammation of the liver;
- disturbances of the gut such as diarrhoea constipation nausea vomiting or abdominal pain;
- disturbances in the normal numbers of blood cells in the blood;
- disturbance in liver function;
- cholestatic jaundice;
- allergic skin rashes;