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Aprepitant Indications

Aprepitant is indicated for the prevention of nausea and vomiting associated with cancer chemotherapy and surgery.
Aprepitant is indicated for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including high-dose cisplatin (in combination with other antiemetic agents).
Aprepitant belongs to a family of drugs called neurokinin 1 (NK1) antagonists.

Aprepitant, in combination with other drugs that prevent vomiting (antiemetics), is indicated to prevent vomiting and nausea associated with the following:
- Cancer chemotherapy wherein it prevents both sudden onset and delayed sickness;
- Recovery from surgery;

Aprepitant Interactions

Do not take Aprepitant with any of the following drugs:
- Astemizole (Hismanal);
- Cisapride (Propulsid);
- Pimozide (Orap);
- Terfenadine (Seldane);

Increased risk of cardiotoxicity and arrhythmias:
- Terfenadine;
- Pimozide;
- Cisapride;
- Astemizole;

These CYP3A4 inhibitors increase the effect and toxicity of aprepitant:
- Diltiazem;
- Itraconazole;
- Ketoconazole;
- Nefazodone;
- Nelfinavir;
- Ritonavir;
- Troleandomycin;

Aprepitant may change levels of chemotherapy agent:
- Paclitaxel;
- Irinotecan;
- Imatinib;
- Ifosfamide;
- Etoposide;
- Docetaxel;

Aprepitant may change levels of chemotherapy agent:
- Vinorelbine;
- Vincristine;
- Vinblastine;

These CYP3A4 inducers decrease the effect of aprepitant:
- Rifampin;
- Phenytoin;
- Mephenytoin;
- Fosphenytoin;
- Ethotoin;
- Erythromycin;
- Clarithromycin;
- Carbamazepine;

Aprepitant Side Effects

Aprepitant side effects that you should report to your health care professional or doctor as soon as possible:
- Weakness/fatigue;
- Stomach ache;
- Nausea;
- Hiccups;
- Heartburn;
- Dizziness;
- Diarrhea;
- Dehydration;
- Anorexia (loss of appetite);
- Abdominal pain/discomfort;

Aprepitant Other Brand Names

In some countries Aprepitant may also be known as:
- Emend;