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Duloxetine Indications

In the brain these chemicals control how we feel and it is thought that low levels can lead to depression and anxiety. By increasing the amount of these chemicals, the mood improves.
In stress urinary incontinence, duloxetine increases the strength of the muscles that control the flow of urine which in turn helps to prevent any leakage.
Duloxetine works by increasing the amount of the chemicals serotonin and noradrenaline within nerves.
Duloxetine is indicated for treatment of anxiety, depression, fibromyalgia, and diabetic neuropathy.
Duloxetine is indicated for the treatment of major depressive disorder (MDD).
Duloxetine is indicated for the treatment of major depressive disorder (MDD), peripheral neuropathic pain caused by diabetes, generalized anxiety disorder (GAD), and (in the US), fibromyalgia.

Duloxetine Contraindications

Duloxetine is contraindicated if you have any of the following conditions:
- If you are pregnant, trying for a baby or breast-feeding;
- If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines;
- If you are under 18 years of age;
- If you have a bleeding disorder or a tendency to develop bruises;
- If you have ever had an allergic reaction to this or any other medicine;
- If you have ever suffered from fits or convulsions;
- If you have ever suffered from mania (great excitement, hallucinations, difficulty in concentrating or being still);
- If you have glaucoma or increased eye pressure;
- If you have heart problems or hypertension (raised blood pressure);
- If you have liver or kidney problems;
- If you have taken a monoamine oxidase inhibitor (MAOI) antidepressant within the last two weeks;

Duloxetine Interactions

Do not take Duloxetine with any of the following drugs:

Possible increase in the levels of this agent when used with duloxetine:
- Propafenone;
- Nortriptyline;
- Imipramine;
- Flecainide;
- Desipramine;
- Amitriptyline;

Possible severe adverse reaction with this combination:
- Tranylcypromine;
- Rasagiline;
- Phenelzine;
- Isocarboxazid;

Duloxetine Side Effects

Duloxetine side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- Anorexia (loss of appetite);
- Asthenia (feelings of weakness);
- Blurred eyesight;
- Changes in weight;
- Constipation;
- Cough;
- Decreased appetite;
- Diarrhea;
- Diarrhoea;
- Difficulty sleeping;
- Dizziness;
- Drowsiness;
- Dry mouth;
- Dyspepsia (indigestion);
- Erectile Dysfunction;
- Fatigue;
- Feeling anxious;
- Feeling or being sick;
- Fever;
- Flushes;
- Frequent daytime urination (pollakiuria);
- Headache;
- Increased sweating;
- Indigestion;
- Insomnia;
- Itching;
- Lack of appetite;
- Loose stools;
- Muscle cramp;
- Myalgia (muscle aches);
- Nasopharyngitis (common cold symptoms);
- Nausea;
- Palpitations;
- Restlessness;
- Sexual problems;
- Shakiness;
- Somnolence (sleepiness);
- Sore throat;
- Sweating;
- Tingling of the skin;
- Tiredness;
- Tremor;
- Vomiting;

Duloxetine Overdose

Reported Duloxetine overdose symptoms are:
- Convulsions;
- Intermittent tremors;
- Reduced activity;
- Rigidity;
- Slow pupillary response;
- Tremors;

Duloxetine Other Brand Names

In some countries Duloxetine may also be known as:
- Yentreve;
- Cymbalta;