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Entacapone Indications

Entacapone is indicated by people who have been suffering from Parkinson's disease for a while and whose symptoms deteriorate between doses.
Entacapone is indicated for as an adjunct to levodopa / carbidopa to treat patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose "wearing-off".
Entacapone is indicated to treat Parkinson Disease in combination with the standard levodopa/carbidopa therapy.
Entacapone is indicated to treat people with Parkinson disease taking the standard levodopa/carbidopa therapy who experience end-of-dose "wearing-off" symptoms.
Entacapone works by increasing the effectiveness of levodopa.
Levodopa is converted into dopamine and so increases the level of dopamine in the brain.
The cause of Parkinson's disease is still unknown but its symptoms of tremor, stiffness and slow movement are due to there being less of a chemical called dopamine in the brain.
The symptoms include a return of the rigidity and immobility associated with the disease.
The symptoms of Parkinson disease are caused by degeneration of neurons that release the neurotransmitter dopamine, resulting in insufficient levels.
Wearing off symptoms occur approximately one to two hours after taking levodopa as its concentration in the brain decreases.
You will probably already be taking a medicine called either co-beneldopa or co-careldopa. These contain levodopa which helps relieve the symptoms of Parkinson's disease.

Entacapone Contraindications

Entacapone is contraindicated if you have any of the following conditions:
- If you are pregnant, trying for a baby or breast-feeding;
- If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines This is especially important if you have recently taken antidepressants known as monoamine oxidase inhibitors (MAOI's);
- If you have ever had an allergic reaction to this or any other medicine;
- If you have ever suffered from neuroleptic malignant syndrome (a reaction to neuroleptic or antipsychotic medicines);
- If you have ever suffered from rhabdomyolysis (a condition affecting the muscles);
- If you suffer from liver problems;
- If you suffer from phaeochromocytoma (a growth affecting the adrenal glands);

Entacapone Interactions

Do not take Entacapone with any of the following drugs:
- Alpha-methyldopa;
- Apomorphine (Apokyn);
- Bitolterol (Tornalate);
- Dobutamine (Dobutrex);
- Dopamine;
- Epinephrine (adrenaline);
- Norepinephrine (noradrenaline);

Increases the effect and toxicity of sympathomimetics:
- Norepinephrine;
- Methyldopa;
- Isoproterenol;
- Isoetharine;
- Epinephrine;
- Dopamine;
- Dobutamine;
- Bitolterol;
- Bitolterol;
- Apomorphine;

Possible hypertensive crisis with this combination:
- Tranylcypromine;
- Phenelzine;
- Isocarboxazid;

Entacapone Side Effects

Entacapone side effects that you should report to your health care professional or doctor as soon as possible:
- Urine discoloration;
- Uncontrolled or unusual body movements;
- Tiredness;
- Sweating;
- Skin rash;
- Seeing or hearing things that are not real;
- Nausea;
- Hallucinations;
- Feeling or being sick;
- Dyskinesia/hyperkinesia (abnormal muscular activity);
- Dry mouth;
- Drowsiness;
- Dizziness;
- Difficulty sleeping;
- Diarrhoea;
- Diarrhea;
- Constipation;
- Confusion;
- Abdominal pain;

Entacapone Overdose

Reported Entacapone overdose symptoms are:
- Abdominal pain;
- Constipation;
- Diarrhea;
- Dizziness;
- Dyskinesia;
- Fatigue;
- Gastrointestinal effects;
- Hallucinations;
- Hyperkinesia;
- Hypokinesia;
- Nausea;
- Severe rhabdomyolysis;
- The occurrence of orthostatic hypotension;

Entacapone Other Brand Names

In some countries Entacapone may also be known as:
- Comtess;
- Comtan;