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Temozolomide Indications

Both diseases are forms of a malignant brain cancer.
For the treatment of newly diagnosed glioblastoma multiforme, temozolomide is indicated concurrently with radiation therapy and then by itself as maintenance treatment.
In glioblastoma multiforme, temozolomide is used alongside radiotherapy, and in malignant glioma Temozolomide is indicated when other treatments have not been successful.
Temozolomide is indicated for the treatment of adult patients diagnosed with anaplastic astrocytoma who have relapsed following chemotherapy.
Temozolomide is indicated for the treatment of adults with newly diagnosed glioblastoma multiforme.
Temozolomide is indicated for the treatment of adults with refractory anaplastic astrocytoma.
Temozolomide is indicated in people with anaplastic astrocytoma for whom treatment with the standard chemotherapy of nitrosurea (Temodar) and procarbazine (Matulane) was ineffective (i.e., refractory disease).
Temozolomide is indicated to treat glioblastoma multiforme and malignant glioma, both forms of brain cancer.
Temozolomide works by preventing the growth and division of cells and therefore stops cancer cells increasing in numbers.

Temozolomide Contraindications

Temozolomide is contraindicated if you have any of the following conditions:
- Caution is used in patients with severe liver or kidney impairment;
- If you are over 70 years of age;
- If you are pregnant or breast-feeding;
- If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines;
- If you are trying for a baby or intend to have children in the future (This applies to both men and women);
- If you have ever had an allergic reaction to this or to any other medicine;
- If you have kidney or liver problems;
- If you have suffered from severe sickness after taking temozolomide previously;
- Patients with glioblastoma multiforme need to be treated to prevent infection by Pneumocystis carinii pneumonia (PCP) when undergoing therapy with radiation and temozolomide;
- Temozolomide is not prescribed to patients who have a history of hypersensitivity or allergy to dacarbazine because the drugs are metabolized into the same active compound;
- Temozolomide may complicate pregnancy and harm the fetus;

Temozolomide Side Effects

Temozolomide side effects that you should report to your health care professional or doctor as soon as possible:
- Anorexia;
- Anxiety;
- Blurred vision;
- Changes in weight;
- Confusion;
- Constipation;
- Convulsions;
- Cough;
- Diarrhoea;
- Difficulty hearing;
- Difficulty sleeping;
- Dizziness;
- Drowsiness;
- Dry mouth;
- Dry skin;
- Fatigue;
- Feeling or being sick;
- Hair loss;
- Headache;
- Infections;
- Loss of appetite;
- Loss of hair;
- Low blood platelet count;
- Mood changes;
- Muscle pain or weakness;
- Nausea;
- Oral thrush;
- Rash;
- Sore mouth;
- Swollen legs;
- Unsteadiness;
- Urinary incontinence;
- Vomiting;

Temozolomide Other Brand Names

In some countries Temozolomide may also be known as:
- Temodar;
- Temodal;